Serra San Bruno is a comune (municipality) in the Province of Vibo Valentia in the Italian region Calabria, located about 40 kilometres (25 mi) southwest of Catanzaro and about 25 kilometres (16 mi) southeast of Vibo Valentia. As of 31 December 2004, it had a population of 6,966 and an area of 39.6 square kilometres (15.3 sq mi).
Close by is the famous Carthusian monastery, Serra San Bruno Charterhouse (Certosa di Santo Stefano di Serra San Bruno), around which the town grew up. The town is named afterSaint Bruno of Cologne, who founded the Carthusian Order in 1053 and the Grande Chartreuse, mother house of the Carthusians, near Grenoble, in France. He built the charterhouse of Serra San Bruno in 1095, and died here in 1101.
The municipality of Serra San Bruno contains the frazione (subdivision) Ninfo.
The movie Le Quattro Volte was filmed in this town.